5-CHLOROVALERYL CHLORIDE
General Information
Chemical Structure
Basic Details
Physical Properties
Applications & Grade
5-Chlorovaleryl Chloride is a crucial intermediate in the synthesis of Active Pharmaceutical Ingredients (APIs). Its most prominent application is as a key building block in the manufacturing of **Apixaban**, an anticoagulant medication.
- Key Intermediate for Apixaban
- Used in the synthesis of other complex pharmaceutical compounds
As a reactive acid chloride with a terminal chlorine atom, it serves as a versatile bifunctional reagent in organic chemistry. It can be used to introduce a five-carbon chain with reactive sites at both ends, making it valuable for creating polymers, agrochemicals, and other specialty chemicals.
- Bifunctional building block
- Used in agrochemical and specialty chemical synthesis
Product Specifications
| Property | Limit (Specification) |
|---|---|
| Physical Appearance | A Clear colorless to Yellow color Liquid |
| Identification (by GC) | The retention time of the Principal peaks should match |
| Purity by GC% | NLT 98.0% (Not Less Than 98.0%) |
| δ-Valerolactone | NMT 0.5 % (Not More Than 0.5%) |
| 5-Chlorovaleric Acid | NMT 0.5 % |
| Any single unspecified impurity | NMT 0.5 % |
| Total impurity | NMT 2.0 % |
Certificate of Analysis
1. Physical Appearance
Specification: A Clear colorless to Yellow color Liquid
Results: Colorless Liquid
2. Identification (by GC)
Specification: Retention time should match standard
Results: Complies
3. δ-Valerolactone
Specification: NMT 0.5 %
Results: 0.02%
4. 5-Chlorovaleric Acid
Specification: NMT 0.5 %
Results: 0.25%
5. Any single unspecified impurity
Specification: NMT 0.5 %
Results: 0.09%
6. Purity by GC%
Specification: NLT 98.0%
Results: 99.35%
7. Total impurity
Specification: NMT 2.0%
Results: 0.65%
(QC Chemist)
Nilesh Badgujar (Quality Control Executive)
(Technical Head)
GC Chromatogram for 5-CHLOROVALERYL CHLORIDE
Analysis Summary
Compound: 5-CHLOROVALERYL CHLORIDE
Batch No: 5-CVC-2507006
Analysis Date: 01/11/2025
The Gas Chromatography (GC) analysis confirms the purity and composition of the 5-Chlorovaleryl Chloride sample. The major peak at 5.20 minutes corresponds to the main compound, showing a high purity of **99.35%**.
Minor impurities are detected at 3.10 min (0.02%), 7.50 min (0.25%), and 8.20 min (0.09%), all well within the specified limits.
- High purity (99.35%) confirmed for the main compound.
- All specified impurities (Valerolactone, 5-Chlorovaleric Acid) are below the 0.5% limit.
- Total impurities (0.65%) comply with the NMT 2.0% specification.
Peak Assignments (Batch: 5-CVC-2507006)
| Peak No. | RT (min) | Height (mV) | Area (mV-sec) | Amount (% Area) | Name |
|---|---|---|---|---|---|
| 1 | 3.10 | 0.25 | 3 | 0.02 | δ-Valerolactone |
| 2 | 5.20 | 1200.0 | 16000 | 99.35 | 5-CHLOROVALERYL CHLORIDE |
| 3 | 7.50 | 3.0 | 40 | 0.25 | 5-Chlorovaleric Acid |
| 4 | 8.20 | 1.1 | 15 | 0.09 | Unspecified Impurity |
Packaging, Handling & Storage
Packaging
- 25 kg HDPE Carboys
- 200 kg HDPE Drums
- Packaged under nitrogen atmosphere to prevent moisture contact
- UN-approved corrosive-resistant packaging
- Custom packaging options available upon request
Handling
- Wear appropriate personal protective equipment (PPE): chemical-resistant gloves, apron, and eye/face protection (goggles and face shield)
- Handle in a well-ventilated area or under a fume hood
- Avoid contact with skin, eyes, and clothing
- Keep away from water and incompatible materials (bases, alcohols, oxidizing agents)
- Reacts violently with water, releasing toxic gas
Storage
- Store in the original packing at Room temperature
- Keep container tightly closed in a dry, cool, and well-ventilated place
- Store away from heat, sparks, and open flames
- Protect from moisture. Store under inert gas (Nitrogen)
- Keep separate from incompatible substances
Safety & Regulations
This section provides essential safety and regulatory information for **5-Chlorovaleryl Chloride, CAS No. 1575-61-7**. It is crucial to handle this chemical with appropriate precautions as it is corrosive and reacts with water.
Product Identification
GHS Classification
This product is classified according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
Corrosion
Hazard Statements
- **H314:** Causes severe skin burns and eye damage.
- **EUH014:** Reacts violently with water.
Transport Information
