4-AMINO-5-CHLORO-2,1,3-BENZOTHIADIAZOLE
General Information
Chemical Structure
Basic Details
Physical Properties
Applications & Grade
4-Amino-5-chloro-2,1,3-benzothiadiazole is a key intermediate in the synthesis of **Tizanidine HCl**, a widely used medication for managing spasticity (muscle stiffness and tightness). It functions as a central alpha-2 adrenergic agonist.
- Tizanidine HCl Intermediate
Used as a building block in organic synthesis for creating complex heterocyclic compounds, particularly in agrochemical and research fields where the benzothiadiazole moiety is of interest.
- Synthesis of heterocyclic compounds
- Agrochemical research
Product Specifications
| Property | Value |
|---|---|
| Appearance | Yellow to brown color Powder |
| Solubility | Soluble in Methanol and Ethyl Acetate |
| Melting Range | 87-90°C |
| Identification HPLC | The retention time of the main peak... should match... standard... |
| LOD | NMT 0.5% |
| Chromatographic Purity By HPLC (Tiza Amine) | NLT 99.0% |
| Single maximum unknown impurity | NMT 0.5% |
| Total impurities | NMT 2.0% |
Certificate of Analysis
Appearance
Specification: Yellow to brown color Powder
Results: Yellow colored powder
Solubility
Specification: Soluble in Methanol and Ethyl Acetate
Results: Complies
Melting Range
Specification: 87-90°C
Results: Complies
Identification HPLC
Specification: RT of main peak should match standard
Results: Complies
LOD
Specification: NMT 0.5%
Results: 0.35%
Purity By HPLC (Tiza Amine)
Specification: NLT 99.0%
Results: 99.3%
Single maximum unknown impurity
Specification: NMT 0.5%
Results: 0.4%
Total impurities
Specification: NMT 2.0%
Results: 0.7%
Q.C. Chemist
Nilesh Badgujar (Quality Control Executive)
Q.C. Manager
HPLC Chromatogram Analysis
HPLC Chromatogram (Batch SS/Tiza/06)
Peak Distribution
Peak Table (Batch SS/Tiza/06)
| Peak | Retention Time (min) | Area | Height | Area % | Name |
|---|
Analysis Summary
The chromatogram shows a main peak at **8.15 minutes** corresponding to **4-Amino-5-chloro-2,1,3-benzothiadiazole**, with a purity of **99.3%**. A single maximum unknown impurity is detected at **6.40 minutes** with an area of **0.4%**. The total impurities are **0.7%**, which complies with the NMT 2.0% specification.
Sample Information
Raw Data (JS / CSV / Python)
JavaScript Object
CSV Format
Python Dict
Packaging, Handling & Storage
Packaging
- 25 kg net in fiber drums
- Custom packaging options available upon request
- Packaged under Nitrogen
Handling
- Wear appropriate personal protective equipment (PPE), including gloves, goggles, and lab coat.
- Ensure adequate ventilation during handling.
- Avoid dust formation and inhalation.
- Wash hands thoroughly after handling.
Storage
- Store in tightly closed container
- Store under Nitrogen
- Suggest at room temperature
- Keep in a dry, cool, and well-ventilated place.
- Protect from direct sunlight and heat sources.
Safety & Regulations
This section provides essential safety and regulatory information for **4-Amino-5-chloro-2,1,3-benzothiadiazole, CAS No. 30536-19-7**. It is crucial to handle this chemical with appropriate precautions.
Product Identification
GHS Classification
This product is classified according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
Harmful / Irritant
Hazard Statements
- **H302:** Harmful if swallowed.
- **H315:** Causes skin irritation.
- **H319:** Causes serious eye irritation.
Transport Information
Downloads
Safety Data Sheet (SDS)
Available on Request. Please contact us for the full SDS.
Certificate of Analysis (COA)
Batch-specific analytical results (Batch: SS/Tiza/06).
Technical Data Sheet (TDS)
Available on Request. Please contact us for detailed specs.
HPLC Analytical Report
Full HPLC chromatogram and peak analysis report.
