3-ACETYLPYRIDINE
General Information
Chemical Structure
Basic Details
Physical Properties
Applications & Grade
3-Acetylpyridine is a key intermediate in the synthesis of numerous Active Pharmaceutical Ingredients (APIs), particularly in oncology and infectious disease treatments.
- Imatinib mesylate (Anti-cancer)
- Nilotinib (Anti-cancer)
- Masitinib (Anti-cancer)
- Telithromycin (Antibiotic)
- Metyrapone (Diagnostic agent)
- Rasitonic acid
As a versatile building block, it is used in the synthesis of various specialty chemicals, agrochemicals, and other complex organic molecules where a 3-pyridyl ketone moiety is required.
- Building block for heterocyclic compounds
- Used in agrochemical research
Product Specifications
| Property | Limit (Specification) |
|---|---|
| Description | Colorless to Yellow color liquid |
| Identification by GC | The retention time of the major peak should match that of the standard. |
| Specific gravity (at 25°C) | 1.10 - 1.12 |
| Water (By KF, %w/w) | Not more than 0.50% |
| Purity (by GC) | Not less than 98.0 % |
| Single maximum impurity | Not more than 1.0 % |
| Total Impurities | Not more than 2.0% |
Certificate of Analysis
1. Description
Specification: Colorless to Yellow color liquid
Results: Pale yellow liquid
2. Identification by GC
Specification: Retention time should match standard
Results: Complies
3. Specific gravity (at 25°C)
Specification: 1.10 - 1.12
Results: 1.116
4. Water (By KF, %w/w)
Specification: Not more than 0.50%
Results: 0.35
5. Purity (by GC)
Specification: Not less than 98.0 %
Results: 99.20
6. Single maximum impurity
Specification: Not more than 1.0 %
Results: 0.45
7. Total Impurities
Specification: Not more than 2.0%
Results: 0.80
(QC Chemist)
Nilesh Badgujar (Quality Control Executive)
(Technical Head)
GC Chromatogram for 3-ACETYLPYRIDINE
Analysis Summary
Compound: 3-ACETYLPYRIDINE
Batch No: 036/0110525
Analysis Date: 03/06/2025
The Gas Chromatography (GC) analysis confirms the purity and composition of the 3-Acetylpyridine sample. The major peak at 6.20 minutes corresponds to the main compound, showing a high purity of **99.20%**.
Minor impurities are detected, with the largest single impurity at 4.80 min (0.45%). The total of all impurities is 0.80%, which complies with the NMT 2.0% specification.
- High purity (99.20%) confirmed for the main compound.
- Single maximum impurity (0.45%) is within the NMT 1.0% limit.
- Total impurities (0.80%) comply with the NMT 2.0% specification.
Peak Assignments (Batch: 036/0110525)
| Peak No. | RT (min) | Height (mV) | Area (mV-sec) | Amount (% Area) | Name |
|---|---|---|---|---|---|
| 1 | 3.50 | 2.0 | 30 | 0.15 | Impurity 1 |
| 2 | 4.80 | 6.0 | 90 | 0.45 | Single Max Impurity |
| 3 | 6.20 | 1500.0 | 19840 | 99.20 | 3-ACETYLPYRIDINE |
| 4 | 7.10 | 2.5 | 40 | 0.20 | Impurity 2 |
Packaging, Handling & Storage
Packaging
- 25 kg HDPE Carboys
- 200 kg HDPE Drums
- UN-approved packaging
- Custom packaging options available upon request
Handling
- Wear appropriate personal protective equipment (PPE): chemical-resistant gloves, safety goggles, and lab coat.
- Handle in a well-ventilated area or under a chemical fume hood.
- Avoid contact with skin, eyes, and clothing.
- Avoid inhalation of vapor or mist.
- Wash hands thoroughly after handling.
Storage
- Store in the original packing at Room temperature.
- Keep container tightly closed in a dry, cool, and well-ventilated place.
- Store away from strong oxidizing agents and strong acids.
- Keep away from heat, sparks, and open flames.
Safety & Regulations
This section provides essential safety and regulatory information for **3-Acetylpyridine, CAS No. 350-03-8**. Handle this chemical with appropriate precautions.
Product Identification
GHS Classification
This product is classified according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
Harmful / Irritant
Hazard Statements
- **H302:** Harmful if swallowed.
- **H315:** Causes skin irritation.
- **H319:** Causes serious eye irritation.
- **H335:** May cause respiratory irritation.
Transport Information
